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China-BE-BE Azienda Directories
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Azienda News:
- CHEK2-Associated Cancer Risk and Screening Recommendation Updates
The NCCN revised the estimated absolute risk for colon cancer from 5%–10% to “No increased risk ” Now, unless there is a family history of colon cancer, NCCN recommends colon cancer screening per general population screening guidelines for patients who carry a CHEK2 pathogenic variant
- Cancer Risk Management for People with a CHEK2 Mutation
People with an inherited mutation in the CHEK2 gene have options for managing their cancer risk Learn about the risk-management guidelines FORCE is here to guide you
- Information for families with a pathogenic variant in the CHEK2 gene
What are the medical care recommendations? Current medical care recommendations for people with CHEK2 pathogenic variants focus on cancer surveillance (also referred to as ‘screening’) The purpose of surveillance is to diagnose cancer at as early a stage as possible
- Clinician Management Resource for CHEK2 - Ambry Gen
General population screening for colorectal cancer is appropriate for patients with pathogenic variants in CHEK2
- CHEK2 Mutation: Everything You Need to Know
Cancer Screening Recommendations for CHEK2 Mutation Carriers Carriers of CHEK2 mutations require tailored cancer screening plans to monitor for potential malignancies Common recommendations include: Breast Cancer: Annual mammograms and breast MRI starting at age 40, or earlier depending on family history
- ACMG PRACTICE RESOURCE: Management of individuals with germline . . .
Systematic prospective data collection is needed to establish the spectrum of CHEK2- associated cancer risks and to determine yet-unanswered questions, such as the outcomes of surveillance, response to cancer treatment, and survival after cancer diagnosis Keywords: Cancer predisposition, Cancer risk, Cancer surveillance, CHEK2, Inherited cancer
- CHEK2 gene - Myriad Genetics
Currently there are no specific medical management guidelines for male breast cancer risk in mutation carriers However, the increase in risk warrants consideration of options for male breast cancer screening, such as patient breast awareness education and clinical breast examinations
- About Mutations in the CHEK2 Gene - Memorial Sloan Kettering Cancer Center
Some examples of these cancer screenings include: Breast magnetic resonance imaging (MRI) scans and mammograms (X-rays of your breast) Colonoscopies starting at an earlier age and more often than most people Your genetic counselor will also talk with you about whether there are any other screening or prevention options that may be right for you
- Management of individuals with germline pathogenic likely pathogenic . . .
Systematic prospective data collection is needed to establish the spectrum of CHEK2-associated cancer risks and to determine yet-unanswered questions, such as the outcomes of surveillance, response to cancer treatment, and survival after cancer diagnosis
- CHEK2 Germline Pathogenic Variant Carriers Management Guidelines for . . .
• Biallelic CHEK2 heterozygotes have been shown to have a higher risk for invasive BC, are more likely to be diagnosed at or before age 50, and are more likely to have multiple primary BCs However, lifetime risk estimates are difficult to quantify due to small study sizes
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