Inherent X-Linked Genetic Variability and Cellular Mosaicism . . . We conclude that sex-related differences in a variety of disease processes including the innate inflammatory response to injury and infection may be related to the abundance of X-linked polymorphic immune-competent genes, differences in ChrX regulation, and inheritance patterns between the sexes and the presence of X-linked cellular mosaicism
The X chromosome in immune functions: when a . . . - Nature Both X-linked genes and sex hormones produced by the gonads influence sex-specific immune responses X-linked genes, autosomal genes and sex hormones can operate together or act individually on
Influence of sex and genetic variability on expression of X . . . The majority of X-linked transcripts were detected with similar detection rates in males and females (Supplementary Fig 1) XIST (X (inactive)-specific transcript), the gene responsible for inactivation of one of the X copies in females, was expressed at low levels, yet higher than the background signal, in 62% of males
The conneXion between sex and immune responses | Nature . . . The contributions of X-linked immune-related genes to sex-biased responses to pathogens are highlighted by sex-specific phenotypes in mice with deletions of particular genes and by patients with