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Canada-BC-CASTLEGAR Azienda Directories
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Azienda News:
- TERT , a promoter of CNS malignancies - PubMed Central (PMC)
In this review, we outline normal telomere biology and regulation of TERT We discuss the mechanisms of TERT upregulation and its role in cancer, focusing on glioblastoma and other CNS tumors We also describe the clinical and prognostic relevance of TERT mutations in CNS tumors
- 7015 - Gene ResultTERT telomerase reverse transcriptase [ (human)]
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat
- Understanding TERT Promoter Mutations: A Common Path to Immortality
Transcriptional activation of TERT, via promoter mutation or other mechanisms, is the rate-limiting step in production of active telomerase Although TERT is expressed in stem cells, it is naturally silenced upon differentiation
- Telomerase Reverse Transcriptase - an overview - ScienceDirect
Telomerase reverse transcriptase is a catalytic subunit of telomerase that delays apoptosis Both intronic and noncoding variants in TERT have been identified as prostate cancer risk SNPs in recent GWAS [39,40]; the rs2736098 noncoding SNP has also been associated with prostate-specific antigen (PSA) variation [41]
- TSW :: Repository Home
We present a theoretical framework for linear regression distillation based on its bilevel optimization structure, deriving closed-form solutions and convergence guarantees that allow for distilled datasets smaller than the input dimension under suitable learning rates
- Terp Young Scholars | University of Maryland Extended Studies - UMD
This summer, join the University of Maryland’s Terp Young Scholars program for a transformative pre-college experience In just three weeks, high school students (rising grade 10 to graduating grade 12) will have the opportunity to challenge their academic curiosity, connect with faculty, and earn three university credits
- University Library - UTRGV
Welcome to the University of Texas Rio Grande Valley Library site Learn more about the services, resources, and electronic resources and research tools that are available for all students, faculty, staff and university community
- The University of Texas Rio Grande Valley | UTRGV
Home of the #1 University in Texas Popular programs UTRGV TUITION ADVANTAGE This program covers the cost of tuition and mandatory fees for students with a family-adjusted gross income of $125,000 or less
- Sci Adv丨余发星课题组于合作者揭示TERT诱导甲状腺癌去分化机制及靶向策略
2023年8月30日，复旦大学附属肿瘤医院头颈外科王玉龙课题组与复旦大学生物医学研究院\复旦大学附属儿科医院 余发星 课题组合作，于 Science Advances 在线发表题为 TERT accelerates BRAF mutant-induced thyroid cancer dedifferentiation and progression by regulating
- 甲状腺癌与TERT基因之间的那些事 - 知乎 - 知乎专栏
TERT基因位于染色体5p15 33上，包含16个外显子和15个内含子，编码 端粒酶 逆转录酶，在保持端粒稳定、基因组完整、细胞长期活性和肿瘤细胞无限增殖能力等方面具有重要作用 [7]。 它与端粒酶RNA组分（TERC）共同组成端粒酶，是一种维持细胞内端粒长度的重要物质，因此，它也决定着端粒酶的活性。 在正常细胞中，端粒酶活性通常被严格控制，在大多数组织中水平很低，仅在生殖细胞和造血干细胞等少数细胞中存在并受到高度调控。 而对于肿瘤细胞，超过90％都表现出端粒酶过度表达，从而可以维持或延长端粒的长度，并导致细胞的恶性增殖及永生 [8]。 TERT的激活主要是由于启动子区发生了基因突变，最常见的就是TERT转录起始位点上游124bp的C228T点突变和146bp的C250T点突变。
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