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- JCI - Welcome
In this issue of the JCI, Singh et al present a mouse model of a specific BBS subtype with genetic deletion of the Bbs5 gene The model recapitulates many of the clinical features observed in patients living with BBS5 and sheds light on adipocyte biology, as well as the hypothalamic mechanisms driving hunger- and food-seeking behaviors that
- JCI - About the Journal of Clinical Investigation
You may submit manuscripts for consideration solely by the JCI or select the Dual-Journal Submission option to have your manuscript evaluated by the JCI and JCI Insight Start your submission by accessing your JCI author account
- JCI - Welcome
The Journal of Clinical Investigation; Current issue; Past issues; Specialties; Reviews; Review series; Videos; Conversations with Giants in Medicine
- JCI - Author Information Center
The JCI was founded in 1924 and is published by the American Society for Clinical Investigation (ASCI), a nonprofit honor organization of physician-scientists established in 1908 Impact Factor 13 3 (2023) One of the top journals in the category “Medicine, Research Experimental ”
- JCI - Welcome
The digital version of JCI This Month is free See here for information about subscribing to the print version, which include online access to all JCI articles What are the black and white squares for? You'll notice quick-response codes, or squares, in JCI This Month
- JCI Insight - Welcome
Human T-lymphotropic virus type 1–associated (HTLV-1–associated) myelopathy (HAM, also known as tropical spastic paraparesis) is a rare neurodegenerative disease with largely elusive molecular mechanisms, impeding targeted therapeutic advancements
- JCI - Submission instructions - first
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- JCI Insight - Welcome
The goal of this study was to determine if transplantation of enteric neural stem cells (ENSCs) can rescue the enteric nervous system, restore gut motility, reduce colonic inflammation, and improve survival in the Ednrb-KO mouse model of Hirschsprung disease (HSCR)
- JCI - Welcome
Neutrophils are the most abundant immune cells that constantly patrol or marginate inside vascular beds to support immune homeostasis The extent to which neutrophils undergo reprogramming in response to the changes in vascular architecture and the resultant biological implications of such adaptations remain unclear
- JCI - Central regulation of feeding and body weight by ciliary GPR75
In this issue of the JCI, Jiang et al utilized germline mutagenesis to generate a missense variant of GRP75, encoded by the Thinner allele, which resulted in mice with a lean phenotype GPR75 accumulated in the cilia of hypothalamic neurons
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