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USA-NM-HOBBS Azienda Directories
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Azienda News:
- Sirolimus-associated pulmonary toxicity - PubMed
The temporal relationship between sirolimus exposure and onset of pulmonary symptoms in the absence of infectious causes and other alternative pulmonary disease and the associated clinical and radiologic improvement after its cessation suggests a causal relationship
- Sirolimus-induced interstitial lung disease and resolution after . . .
After an exhaustive work-up to exclude infectious causes and other pulmonary diseases, the diagnosis of sirolimus-associated pulmonary toxicity was made In November 2017, sirolimus was discontinued and she was switched to everolimus at 0 75 mg twice daily The level was maintained at 4–8 ng ml
- SIROLIMUS-ASSOCIATED PULMONARY TOXICITY - LWW
Here, we describe three cases of suspected pulmonary toxicity associated with sirolimus therapy and review the literature on previously reported cases of “sirolimus-induced interstitial pneumonitis ”
- ACUTE RESPIRATORY DISTRESS SYNDROME SECONDARY TO SIROLIMUS . . . - CHEST
Radiographic findings mimic other pulmonary syndromes, making diagnosis more difficult We present an unusual case of sirolimus-induced pulmonary toxicity leading to severe hypoxemia, with manifestations of both diffuse alveolar hemorrhage (DAH) and organizing pneumonia (OP)
- Pneumonitis associated with sirolimus: clinical characteristics, risk . . .
A sirolimus blood trough level above 12 μg l may increase the risk, but pneumonitis may also occur at blood trough levels as low as 6 μg l Since pneumonitis may recur during low-dose sirolimus treatment, discontinuation of sirolimus appears to be the safest treatment option
- Risk factors for and management of sirolimus-associated . . . - Nature
Weiner et al review recent clinical information on the development of pulmonary toxicity in renal, renal–pancreas or pancreas transplant recipients given sirolimus
- Acute Fibrinous and Organizing Pneumonia Due to Sirolimus Induced Lung . . .
Here we present a case of sirolimus-induced lung toxicity with a biopsy demonstrating acute fibrinous and organizing pneumonia (AFOP), a histological finding rarely seen as a result of sirolimus toxicity
- Sirolimus-induced pneumonitis - PMC
The mechanism of pulmonary toxicity of Sirolimus (rapamycin) is not clear; direct toxicity, immunomediated toxicity, or both have been proposed as the mechanism The presence of lymphocytes in lung biopsies suggests an immunomediated mechanism
- Acute respiratory distress attributed to sirolimus in solid organ . . .
Pulmonary toxicity has frequently been recognized as a potentially serious complication associated with sirolimus therapy It consists of a wide spectrum of syndromes most characterized by the presence of lymphocytic alveolitis and lymphocytic interstitial pneumonitis
- Sirolimus-induced pulmonary toxicity without recurrence more than 8 . . .
Due to the possibility of drug toxicity, sirolimus was discontinued, and the corticosteroid dose was increased (50 mg day) Constitutional symptoms, e g , fever and dyspnea, have immediately improved
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