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- Microglia - Wikipedia
Microglia are a type of glial cell located throughout the brain and spinal cord of the central nervous system (CNS) [1] Microglia account for about around 5–10% of cells found within the brain [2][3] As the resident macrophage cells, they act as the first and main form of active immune defense in the CNS [4]
- Microglia | Description Function | Britannica
Microglia, type of neuronal support cell (neuroglia) in the central nervous system of invertebrates and vertebrates that mediates immune responses by acting as macrophages, clearing cellular debris and dead neurons from nervous tissue through the process of phagocytosis (cell eating)
- Generating microglia from human pluripotent stem cells: novel in vitro . . .
We review novel insights into microglia biology and the role of microglia in neurological diseases as drawn from the new methods and provide an outlook for future lines of research involving human pluripotent stem cell-derived microglia
- The Origin of Microglia and the Development of the Brain
Unlike astrocytes, oligodendrocytes, and neurons, which are derived from neuroectoderm, microglial cells originate from mesoderm Microglial hematopoietic precursors enter the developing CNS from the bloodstream, ventricles, and meninges
- Microglia-macrophages - Neuropathology
Activated microglial cells have large rod-shaped nuclei and greatly ramified cytoplasm They encircle degenerating neurons (neuronophagia) and form clusters around small foci of necrotic brain tissue (microglial nodules) They can also transform into brain macrophages
- Origin and Emergence of Microglia in the CNS—An Interesting . . . - MDPI
Microglial cells are unique tissue-resident macrophages that differ from their hematogenous origins due to their surrounding environment, which is immune-privileged owing to the formation of the blood–brain barrier (BBB) The timing of BBB formation is vital for the invasion of microglia progenitors during embryonic development
- The human microglial HMC3 cell line: where do we stand? A systematic . . .
The human microglial clone 3 cell line, HMC3, was established in 1995, through SV40-dependent immortalization of human embryonic microglial cells It has been recently authenticated by the American Type Culture Collection (ATCC®) and distributed under the name of HMC3 (ATCC®CRL-3304)
- The ins and outs of microglial cells in brain health and disease
Microglial cells derive from primitive macrophages that originated in the yolk sac during early embryonic development, setting them apart transcriptionally from other tissue-resident macrophages and bone marrow-derived macrophages (Figure 1) (10, 12)
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