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Italy-SC-SC Azienda Directories
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Azienda News:
- Clostridioides difficile Toxins: Host Cell Interactions and Their Role . . .
Toxins damage the colonic epithelium, initiating a cascade of cellular events that lead to inflammation, fluid secretion, and further tissue damage within the colon
- Differential effects of Clostridium difficile toxins on ion secretion . . .
Serosal addition of TcdB induced epithelial damage consistent with its cytotoxic effect However, mucosal addition of TcdB had similar effects, but only in the presence of TcdA
- Clostridium difficile - an overview | ScienceDirect Topics
Pathogenic strains of the organism produce two distinct toxins, both of which are high-molecular weight proteins capable of binding to specific receptors on the intestinal mucosal cells: (1) toxin A, an enterotoxin and (2) toxin B, a cytotoxin (Gibbs, 2009)
- Frontiers | Characterization of the Adherence of Clostridium difficile . . .
In this context, we sought to characterize the adherence properties of spores from an epidemic C difficile strain to components of the intestinal mucosa, such as intestinal epithelial cell lines, porcine stomach mucin, fibronectin and vitronectin
- Clostridium difficile - Wiley Online Library
Clostridium difficile produces three main toxins: Toxin A (TcdA), Toxin B (TcdB), and Clostridium difficile binary toxin (CDT) TcdA and TcdB are recognized by Toll-like receptor 4 (TLR4), triggering an intestinal inflammatory response
- Microbes and Microbial Toxins: Paradigms for Microbial- Mucosal . . .
C difficile toxin A exerts its potent secretory and necroinflammatory responses in mammalian intestine by a separate neural pathway involving the activation of mucosal mast cells and release of SP and CGRP from sensory neurons
- Clostridioides difficile Toxins: Host Cell Interactions and Their Role . . .
Toxins damage the colonic epithelium, initiating a cascade of cellular events that lead to inflammation, fluid secretion, and further tissue damage within the colon
- Clostridium difficile Infection | Nutritional Immunology and Molecular . . .
C difficile toxins TcdA and TcdB breach the intestinal barrier and trigger mucosal inflammation and intestinal damage The inflammasome is an intracellular danger sensor of the innate immune system
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