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USA-TX-SPRING Azienda Directories
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Azienda News:
- Delivery of Oligonucleotide Therapeutics: Chemical . . .
In addition to the current repertoire of chemical modifications, there is a growing focus on developing synthetic and biological nanoparticles for ON delivery In this review, we look into two nanoparticle-based approaches that are used to enhance delivery: lipid nanoparticles (LNPs) and extracellular vesicles (EVs)
- Oligonucleotide therapeutics and their chemical modification . . .
In this review, we provide a comprehensive overview of oligonucleotide therapeutics and their associated chemical modification approaches, highlighting their potential in the clinical realm
- Delivery of Oligonucleotide Therapeutics: Chemical . . .
SSOs are designed to utilize chemical modifications which increase their stability, cellular delivery, and binding affinity These include for example morpholinos, 2′-OMe phosphorothioate, LNAs, and other modified nucleotides
- Delivery of Oligonucleotide Therapeutics: Chemical . . .
There are a range of approaches to overcome this, and in this review, we focus on three: altering the chemical structure of the ONs, formulating synthetic, lipid-based nanoparticles to encapsulate the ONs, or biologically loading the ONs into extracellular vesicles
- Strategies to Enhance Oligonucleotide Drug Delivery - BOC Sci
Chemical modification represents one of the most effective approaches to enhance oligonucleotide drug delivery Modification of the nucleic acid backbone, the ribose sugar moiety and the nucleobase itself has been extensively employed in order to improve the drug-like properties of oligonucleotide drugs and thereby enhance delivery
- Advances in oligonucleotide drug delivery | Nature Reviews . . .
Oligonucleotides can be used to modulate gene expression via a range of processes including RNAi, target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA
- Oligonucleotide Drugs: Breakthroughs, Delivery, and Stability
Antisense oligonucleotides (ASOs) are short, synthetic strands of nucleic acids that bind to specific mRNA sequences, thereby modulating gene expression By binding to target mRNA, ASOs can inhibit the translation of specific proteins, offering a precise approach to disease intervention
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