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Canada-ON-WATERLOO Azienda Directories
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Azienda News:
- WNK kinases sense molecular crowding and rescue cell volume . . .
Within seconds of cell exposure to hypertonicity, WNK1 concentrates into membraneless condensates, initiating a phosphorylation-dependent signal that drives net ion influx via the SLC12 cotransporters to restore cell volume
- WNK1 kinase balances T cell adhesion versus migration in vivo
We found that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2 WNK1-deficient T cells home less efficiently to lymphoid organs and migrate more slowly through them
- T cell migration requires ion and water influx to regulate . . .
We show that chemokine receptor signaling in migrating T cells activates WNK1, transducing signals via OXSR1 and STK39 and the SLC12A2 ion co-transporter which results in ion influx,
- Key role of ion and water influx in T cell migration uncovered
WNK1 kinase, key in ion regulation in kidneys, also plays a vital role in T cell migration It controls ion influx by activating pathways involving Oxidative-Stress Responsive 1
- T cell migration requires ion and water influx to regulate . . .
We show that chemokine receptor signaling in migrating T cells activates WNK1, transducing signals via OXSR1 and STK39 and the SLC12A2 ion co-transporter which results in ion influx, and subsequent water entry by osmosis, most likely via aquaporins
- WNK1 kinase balances T cell adhesion versus migration in vivo
We demonstrate that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via OXSR1 and STK39 kinases and the SLC12A2 ion co-transporter WNK1-deficient T cells home less efficiently to lymphoid organs, and migrate more slowly through them
- T cell migration requires ion and water influx to regulate . . .
via WNK1 results in ion influx via SLC12A2 which is required for T cell migration Thus, a pathway regulating ion homeostasis plays a critical role in T cell movement
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