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- GPCR-Targeted Therapeutics for Long COVID - GitHub
This research project offers a comprehensive investigation into the therapeutic potential of G Protein-Coupled Receptors (GPCRs) in managing Long COVID Through integrated computational approaches, it identified and prioritized 21 GPCR genes as potential therapeutic targets
- Long COVID: G Protein-Coupled Receptors (GPCRs) Associated Genes and . . .
Long COVID, also referred to as post-COVID-19 condition, describes the lingering after-effects of COVID-19 infection GPCR genes such as HRAS, KRAS, GNAQ, and GNA11 were determined to be possible therapeutic targets for the pathophysiological mechanisms of long COVID FDA-approved drugs targeting these genes were identified, including
- (PDF) Long COVID: G Protein-Coupled Receptors (GPCRs . . . - ResearchGate
Long COVID: G Protein-Coupled Receptors (GPCRs) Associated Genes and Pathways as a Promising Therapeutic Potential Through Computational Analysis August 2024 DOI: 10 20944 preprints202408 0558 v1
- A deep generative model for deciphering cellular dynamics and . . . - Nature
Published: 20 June 2025; 64,107; and GPCR signalling pathways, indicating their potential as therapeutic targets against COVID-19 f, Bar chart outlining the top 10 drug perturbation
- Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches
Indeed, emerging evidence has shown that patients with long COVID-19 are characterized by higher and more persistent levels of SARS-CoV2 antigen-specific follicular CD4+ T and T helper cells than patients with COVID-19 without sequelae [98,103] Persistence of high levels of these immune cells may lead to their exhaustion, as suggested by
- Exploring the mechanisms of long COVID: Insights from . . . - PubMed
Long coronavirus disease (COVID) has emerged as a global health issue, affecting a substantial number of people worldwide However, the underlying mechanisms that contribute to the persistence of symptoms in long COVID remain obscure, impeding the development of effective diagnostic and therapeutic …
- review of COVID-19 biomarkers and drug targets: resources and tools . . .
We started with a set of 27 894 articles downloaded on 20 June 2020 from LitCovid, a curated open-resource literature of PubMed research papers related to COVID-19 and from the COVID-19 SARS-CoV-2 collection of medRxiv and bioRxiv preprint servers The document text content, composed by joining article’s title and abstract, was tokenized
- Long COVID: G Protein-Coupled Receptors (GPCRs) responsible for . . .
As of early December 2022, COVID-19 had a significant impact on the lives of people all around the world, with over 630 million documented cases and over 6 million deaths A recent clinical analysis revealed that under certain conditions, a patient’s disease symptoms are more likely to persist Long COVID is characterised by many symptoms that continue long after the SARS-CoV-2 infection has
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