RINVOQ® (upadacitinib) for Ulcerative Colitis (UC) RINVOQ is a prescription medicine used to treat adults with moderate to severe ulcerative colitis when 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well or could not be tolerated It is not known if RINVOQ is safe and effective in children with ulcerative colitis