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- Genetic and non-genetic clonal diversity in cancer evolution
As clonal diversity can influence the immune response to a developing tumour, this response can provide negative selection pressure on a growing tumour and, in turn, shape its clonal composition
- When, why and how tumour clonal diversity predicts survival
Higher clonal diversity can be associated with slower future tumour growth (a) Correlation coefficients between clonal diversity (measured at a tumour size of 250,000 cells) and subsequent tumour growth rate, plotted against mean clonal turnover index Each point represents a cohort of 100 simulated tumours
- What is the Difference Between Clonal Selection and Clonal . . .
The main difference between clonal selection and clonal expansion is that clonal selection is the process of matching antigens on antigen-presenting cells with the antigen receptors on B and T cells, whereas clonal expansion is the production of genetically identical daughter cells of activated T and B cells by cell division
- Exploring the impact of clonal definition on B-cell diversity . . .
Our contribution in defining clonal diversity and diversity indices is an important step towards a better understanding of the immune system and its role in health and disease 4 Methods 4 1 B cell repertoire preprocessing
- Ch. 8 Clonal diversity, clonal selection and cells associated . . .
Study with Quizlet and memorize flashcards containing terms like Generation of clonal diversity, -central tolerance induced as auto-reactive cells are deleted, Generation of clonal diversity and more
- T-cell repertoire analysis and metrics of diversity and . . .
Diversity metrics variation upon richness and evenness changes (a) Different scenarios of clonal distribution in a repertoire of ten million cells sequenced at the same depth for normalization are represented here The changes in clonality (1-Pielou’s evenness), Shannon entropy, Gini-Simpson index and Gini coefficient are shown in a heatmap
- When, why and how tumour clonal diversity predicts survival
Higher clonal diversity can be associated with slower future tumour growth (a) Correlation coefficients between clonal diversity (measured at a tumour size of 250,000 cells) and subsequent tumour growth rate, plotted against mean clonal turnover index Each point represents a cohort of 100 simulated tumours
- Patho Ch 8 Exam 2 Flashcards - Quizlet
Generation of clonal diversity occurs in the primary lymphoid organs, which includes the thymus (T lymphocytes) and bone marrow (B lymphocytes) Before birth, T and B
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