|
- AMPK and Diseases: State of the Art Regulation by AMPK . . .
Direct AMPK activators showed more promising results in eliminating side effects as well as the possibility to engineer drugs for specific AMPK isoforms activation In this review, we discuss AMPK targeting drugs, especially concentrating on those compounds that activate AMPK by mimicking AMP
- New insights into activation and function of the AMPK
This work demonstrates that agents that damage DNA by distinct mechanisms all activate AMPK in the nucleus by a mechanism involving the Ca 2+ –CaMKK2 pathway, and also shows that AMPK
- AMP-Activated Protein Kinase Is Essential for the Maintenance . . .
Here we provide evidence that AMP-activated protein kinase (AMPK) is pivotal to sustain neuronal energy levels upon synaptic activation by adapting the rate of glycolysis and mitochondrial respiration Furthermore, this metabolic plasticity is required for the expression of immediate-early genes, synaptic plasticity, and memory formation
- New insights into activation and function of the AMPK
The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP ratios Once activated, AMPK acts to restore energy homeostasis by promoting ATP-producing catabolic pathways while inhibit …
- The Energy Sensor AMPK: Adaptations to Exercise, Nutritional . . .
When cellular energy status has been compromised, AMPK is activated by increases in AMP:ATP or ADP:ATP ratios and acts to restore energy homeostasis by stimulating energy production via catabolic pathways while decreasing non-essential energy-consuming pathways
- AMPK activators: mechanisms of action and physiological . . .
As a cellular energy sensor, AMP-activated protein kinase (AMPK) is activated in response to a variety of conditions that deplete cellular energy levels, such as nutrient starvation (especially glucose), hypoxia and exposure to toxins that inhibit the mitochondrial respiratory chain complex 1, 2 AMPK is a serine threonine protein kinase complex
|
|
|