- Benzbromarone - Wikipedia
Benzbromarone is a uricosuric agent and non-competitive inhibitor of xanthine oxidase [1] used in the treatment of gout, especially when allopurinol, a first-line treatment, fails or produces intolerable adverse effects It is structurally related to the antiarrhythmic amiodarone [2]
- Benzbromarone in the treatment of gout | Advances in . . .
Benzbromarone is a safe and effective molecule for the treatment of gout However, due to in vitro and in vivo data related to hepatotoxicity, it is prudent to prescribe it with some caution, especially for patients with an already known liver condition
- Benzbromarone: Uses, Interactions, Mechanism of Action . . .
Benzbromarone is a uricosuric agent which is taken daily for the prevention of gout flares Benzbromarone has been used in trials studying the basic science and treatment of Heart Failure, Hyperuricemia, Chronic Kidney Disease, Abnormal Renal Function, and Gout and Asymptomatic Hyperuricemia The next evolution of DrugBank is here
- Considering Benzbromarone as First-Line Therapy for Gout
In this comparative effectiveness clinical trial, Yan et al set out to compare nontitrated, low-dose benzbromarone with low-dose febuxostat as the first-line therapy in gout patients with renal uric acid underexcretion
- Review of Urate-Lowering Therapeutics: From the Past to the . . .
Benzbromarone Benzbromarone is a nonselective uricosuric that lowers SUA by inhibiting URAT1, with a lesser effect on GLUT9, OAT1, and OAT3 The starting dose is 50 mg daily, with a maximum dose of 200 mg daily Benzbromarone was never approved in the US due to potential hepatotoxicity, although it has been approved in Asia and Europe
- benzbromarone | Dosing Uses - medtigo
benzbromarone is a medication primarily used to treat gout, characterized by elevated levels of uric acid in the blood, which can leads to painful joint inflammation benzbromarone affects the body’s uric acid metabolism, primarily through its actions on the kidneys and liver
- Benzbromarone: A Review of its Pharmacological Properties and . . .
Synopsis: Benzbromarone is a benzofuran derivative which lowers serum urate and increases urinary urate excretion in normal, hyperuricaemic and gouty subjects In open short- and long-term studies benzbromarone reduced serum uric acid levels by one-third to one-half and maintained its effectiveness for periods of up to 8 years
- BENZBROMARONE - National Center for Advancing Translational . . .
Benzbromarone (INN) is a uricosuric agent and non-competitive inhibitor of xanthine oxidase used in the treatment of gout, especially when the first line treatment, allopurinol, fails or produces intolerable adverse effects It is structurally related to the antiarrhythmic amiodarone
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