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- A national study of plasma use in critical care: clinical indications . . .
Introduction Fresh frozen plasma (FFP) is widely used, but few studies have described patterns of plasma use in critical care We carried out a multicentre study of coagulopathy in intensive care units (ICUs) and here describe overall FFP utilisation in adult critical care, the indications for transfusions, factors indicating the doses used and the effects of FFP use on coagulation Methods We
- Balanced massive transfusion ratios in multiple injury patients with . . .
Introduction Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions These results have mostly been derived from non-head-injured patients The
- Prothrombin complex concentrate versus fresh frozen plasma in patients . . .
To reverse oral anticoagulant (OAC) therapy, a number of treatment modalities is available Fresh frozen plasma (FFP) is effective and is currently used for coagulation factor replacement, carrying a risk of volume overload, transmission of infective agents and being time consuming Variable and frequently low potency of clotting factors results in minor haemostatic effects compared with
- Evaluation of the implementation of a massive transfusion protocol
Introduction A massive transfusion protocol (MTP) aims to provide standardized and early delivery of blood products and prohemostatic agents by keeping pre-thawed fresh frozen plasma (FFP) available Implementation of MTP is assumed to result in transfusion with higher ratios of FFPs and platelets to red blood cells (RBCs)
- Effect of early administration of fibrinogen replacement therapy in . . .
Innerhofer et al [14] investigated the use of coagulation factor concentrates (CFC), where all patients received FgC, compared to FFP alone in trau-matic haemorrhage This study was terminated early for futility and safety reasons because of the high proportion of patients in the FFP group who required rescue therapy with CFC [14]
- Guideline-concordant administration of prothrombin complex concentrate . . .
FFP: Fresh frozen plasma GC-PCC-K: Guideline-concordant of administration PCC and Vitamin K GCS: Glasgow coma scale score HR: Hazard ratio ICH: intracranial hemorrhage INR: International normalized ratio OR: Odds ratio PCC: Prothombin concentrated complex SAP: Systolic arterial blood pressure VKA: Vitamin K antagonist
- Pre-hospital plasma transfusion: a valuable coagulation support or an . . .
Moreover, the INR of FFP is 1 3 [6] Any beneficial effect of plasma to correct slightly elevated INR is futile and plasma has primarily an effect on coagulation parameters with extended volumes and performs best in patients bleeding and coagulopathic
- A word of caution on renal risks of prothrombin complex concentrate use . . .
The Original Article was published on 06 January 2016 In a retrospective study of bleeding patients in cardiac surgery, Cappabianca et al [1] observed that the use of prothrombin complex concentrate (PCC) compared with fresh-frozen plasma (FFP) was associated with a higher risk of postoperative renal complications
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