- Managing Influenza as a Coinfection in COPD - Pulmonology Advisor
In addition to the respiratory effects of the virus itself, influenza infection increases the risk for other illnesses, including bacterial and fungal infection, further increasing the risk for mortality and morbidity in patients with COPD 1 For example, acute pneumonia has been diagnosed in 30% to 40% of hospitalized patients with influenza, particularly patients with risk factors, including
- The Effects of Chronic Obstructive Pulmonary Disease (COPD) on the Risk . . .
In this study, we explored the effects of COPD on infection rate and recovery rate of influenza COPD weakens the respiratory system and tissues with symptoms like chronic cough and sputum production (Wheaton et al , 2015) Because of these effects of COPD, the influenza virus can infect lung tissues easier, increasing the susceptibility of
- 2 targets in influenza A virus infection-induced COPD exacerbations
3 47 episodes of worsening in disease symptoms, known as exacerbations Respiratory viral 48 infections, such as those caused by influenza viruses and SARS-CoV-2, are common triggers 49 for exacerbation and contribute significantly to hospitalizations (3) 50 Despite such high prevalence, the underlying mechanisms that contribute to the 51 enhanced susceptibility to viral infection in COPD
- Seasonal influenza vaccination in patients with COPD: a systematic . . .
Background Influenza is a frequent cause of exacerbations of chronic obstructive pulmonary disease (COPD) Exacerbations are associated with worsening of the airflow obstruction, hospitalisation, reduced quality of life, disease progression, death, and ultimately, substantial healthcare-related costs Despite longstanding recommendations to vaccinate vulnerable high-risk groups against
- Influenza vaccination and risk of respiratory failure in patients with . . .
Patients with COPD are at an increased risk for respiratory tract infection, 3, 4 resulting in increased mortality and morbidity 5, 6 Historically, bacteria have been considered the main infectious cause of COPD exacerbations 7 However, a growing body of evidence implicates viral infections in the pathogenesis of COPD and as a major trigger of acute exacerbations 8, 9 Among various viral
- Effectiveness of influenza vaccination in preventing severe COPD . . .
As opposed to a single 1:1 matching, This approach offers increased stability and accuracy compared to commonly used methods, as it produces more stable and generalisable estimates by repeatedly sampling from a large control pool 20–22 We estimated the relative risk (RR) of severe COPD events between the vaccinated and unvaccinated groups for each influenza season To derive 95% confidence
- Use of Inhaled Corticosteroids in Patients With COPD and the Risk of TB . . .
Although an increased risk of pneumonia associated with ICS has been reported in observational studies, 6, 7 large randomized controlled trials, 8, 9 and meta-analyses, 10, 11 few studies have addressed the safety of ICS treatment with respect to other respiratory infections, including TB and influenza Several observational studies have indicated a positive association between ICS and TB, 12
- Acute Respiratory Illness in Patients With COPD and the . . . - CHEST
A significant causative virus related to these exacerbation is influenza virus 6 In addition, viral infections may impair host defenses, 7,8 which leads to increased colonization or infection with pathogenic bacteria Thus, prevention of influenza virus infection in patients with COPD may substantially contribute toward a decrease in morbidity, mortality, and medical resource utilization
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