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- JCI - About the Journal of Clinical Investigation
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Copyright © 2025 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)
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In this issue of the JCI, Singh et al present a mouse model of a specific BBS subtype with genetic deletion of the Bbs5 gene The model recapitulates many of the clinical features observed in patients living with BBS5 and sheds light on adipocyte biology, as well as the hypothalamic mechanisms driving hunger- and food-seeking behaviors that
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- JCI - Central regulation of feeding and body weight by ciliary GPR75
In this issue of the JCI, Jiang et al utilized germline mutagenesis to generate a missense variant of GRP75, encoded by the Thinner allele, which resulted in mice with a lean phenotype GPR75 accumulated in the cilia of hypothalamic neurons
- JCI - Deep immunophenotyping reveals circulating activated lymphocytes . . .
JCI Insight 2016;1 (17):e90045 View this article via: JCI Insight CrossRef PubMed Google Scholar Mankia K, et al EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis Ann Rheum Dis 2021;80 (10):1286–1298 View this article via: CrossRef PubMed Google Scholar
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