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In this issue of the JCI, Singh et al present a mouse model of a specific BBS subtype with genetic deletion of the Bbs5 gene The model recapitulates many of the clinical features observed in patients living with BBS5 and sheds light on adipocyte biology, as well as the hypothalamic mechanisms driving hunger- and food-seeking behaviors that
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Copyright © 2025 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)
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Virus-induced RGMa expression drives neurodegeneration in HTLV-1–associated myelopathy Natsumi Araya, … , Kaoru Uchimaru, Yoshihisa Yamano Published April 30, 2025 Citation Information: JCI Insight 2025; 10 (11):e184530 https: doi org 10 1172 jci insight 184530
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Targeting intracellular LMP2 with costimulatory signal–armed antibody-like TCR T cells Jiali Cheng, … , Taochao Tan, Liang Huang Published May 22, 2025 Citation Information: JCI Insight 2025; 10 (10):e178572 https: doi org 10 1172 jci insight 178572
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