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- JCI - Welcome
In this issue of the JCI, Köcher et al have demonstrated that ERG overexpression in human prostate cancer cells rewired DNA double-strand break repair toward a poly (ADP-ribose) polymerase 1–dependent (PARP1-dependent) alternative end-joining pathway without disrupting canonical repair
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Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)
- JCI - About the Journal of Clinical Investigation
Email staff@the-jci org or call 734-222-6050 To avoid confusion regarding correspondence, inquiries, and decisions, the JCI will typically communicate only with the responsible party corresponding author of submissions
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The JCI considers research submissions in the following categories [Top of page] Click the category name for formatting instructions; or go to How to submit your manuscript for the first time (new windows) Research manuscripts provide substantial new mechanistic insights into biology and disease using preclinical models as well as materials and data derived from humans These manuscripts are
- JCI - AgRP neuron hyperactivity drives hyperglycemia in a mouse model . . .
Effect of AgRP neuron inactivation on food intake, body weight, blood glucose, and plasma insulin levels over 10 weeks in diabetic Lepob ob mice The primary goal of this study was to determine the effect of AgRP neuron inactivation on serial measures of blood glucose over time in a mouse model of T2D Among diabetic Lep ob ob mice in which AgRP neurons were inactivated following
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Liver invasion is one of the most frequent events in the progression of gallbladder cancer (GBC) However, the cellular and pathological role of the tumor-liver–interface microenvironment in liver invasion is still enigmatic Here, we applied single-cell and spatial transcriptomics to systematically investigate the cellular component and gene expression regulation of the microenvironment
- JCI - The gut microbiome and cancer response to immune checkpoint . . .
The field of the microbiome and immunotherapy has skyrocketed since 2015 when two studies demonstrated a fascinating phenomenon in mice: certain gut bacteria could enhance the efficacy of immune checkpoint inhibitor (ICI) therapy in tumors outside of the gut (1, 2) ICIs are a type of cancer immunotherapy in which antibodies that block ICI molecules reinvigorate immune cells to mount a robust
- JCI - The promise of GLP-1 receptor agonists for neurodegenerative diseases
Glucagon-like peptide-1 receptor agonists (GLP-1RAs), established therapies for type 2 diabetes and obesity, are increasingly recognized for their potential in neurodegenerative diseases Preclinical studies across diverse neurodegenerative conditions consistently demonstrate neuroprotective effects of GLP-1RAs, including reduced protein aggregation, enhanced autophagy, improved mitochondrial
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