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  • p53 - 维基百科,自由的百科全书
    p53是一系列 同源异构蛋白 的统称,属于一种腫瘤抑制蛋白,由 TP53 (人体)及 Trp53 (老鼠)基因编码 [10]。 该蛋白是最早发现的 肿瘤抑制基因 所编码的蛋白之一。
  • p53基因_百度百科
    P53基因是人体重要的抑癌基因,位于17号染色体短臂13区 (17p13)。 该基因全长16,000-20,000碱基对,包含11个外显子,编码2 5kb的mRNA,翻译产生53kDa的核内DNA结合蛋白,并因此而得名。
  • Nature Reviews | p53:一种蛋白质,众多靶点 - 知乎
    在生物化学上,p53主要作为一种序列特异性的转录因子,能够与基因组内确定的DNA序列(称为p53反应元件或p53结合位点)结合并激活相邻基因的转录,以及由具有p53结合位点的增强子调节的更远的基因的转录。
  • Tumor Suppressor p53: Biology, Signaling Pathways, and Therapeutic . . .
    This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway
  • TP53 Gene - GeneCards | P53 Protein | P53 Antibody
    p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (e g hypoxia, DNA and spindle damage)
  • Cancer Cell:顾伟 刘彦卿等2万字长文综述全面总结p53领域研究进展_澎湃号·湃客_澎湃新闻-The Paper
    为了抑制p53活性,可以采用多种方法,例如使用p53特异性抑制剂,破坏p53与其激活因子之间的蛋白结合,或增强p53抑制因子的功能。
  • Nature子刊综述:一文说清p53与肿瘤免疫的关系 - 搜狐
    鉴于p53和免疫系统在癌症进展中都至关重要,因此本文讨了论野生型和突变型 p53如何影响许多免疫细胞类型的功能,从野生型p53在调节免疫系统中的作用开始,然后讨论p53的突变形式如何直接或间接影响免疫。
  • p53 - Wikipedia
    p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers




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