- p53 - Wikipedia
p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers
- The TP53 Gene and Its Role in Cancer - Verywell Health
What is TP53 and what role does it play in cancer? The TP53 gene is a gene that is mutated in many cancers It is the most common gene mutation found in cancer cells A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and growth of tumors
- Understanding the complexity of p53 in a new era of tumor suppression
Here, we review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that contribute to tumor suppression
- p53 Signaling Pathway: Insights and Regulatory Mechanisms
Explore the p53 signaling pathway, its regulatory mechanisms, and its role in maintaining cellular integrity and response to stress Home Anatomy and Physiology
- lt;em gt;Journal of Internal Medicine lt; em gt; | Wiley Online Library
The p53 protein is a transcription factor comprising five domains: a transactivation domain divided into two regions responsible for activating the transcription of multiple genes, a proline-rich domain (PRD) involved in the regulation of apoptosis, a 200-amino-acid-residue DNA-binding domain (DBD), a tetramerization domain (TET) that enables
- Unveiling P53s Power: Tumor-Suppressing Functions Explained
The p53 gene, also known as the TP53 gene, provides instructions for making a protein called the tumour protein p53, or simply p53 This protein acts as a tumour suppressor, which means that it regulates cell division by keeping cells from growing and dividing too fast or in an uncontrolled way
- Tumor suppressor p53: Biology, signaling pathways, and . . . - PubMed
This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway
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