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- Pseudouridine - Wikipedia
Pseudouridine is the C5-glycoside isomer of uridine that contains a C-C bond between C1 of the ribose sugar and C5 of uracil, rather than usual C1-N1 bond found in uridine Uridine is converted to pseudouridine by rotating the uridine molecule 180° across its N3-C6 axis [3]
- Pseudouridine Formation, the Most Common Transglycosylation in RNA . . .
Pseudouridine (Ψ) synthases are the enzymes responsible for the most abundant and phylogenetically conserved posttranscriptional modification of cellular RNAs These enzymes catalyze an isomerization reaction of specific uridine residues within an RNA chain
- The Critical Contribution of Pseudouridine to mRNA COVID-19 Vaccines
However, its efficacy was only 48% This striking difference in efficacy could be attributed to the presence of a critical RNA modification (N1-methyl-pseudouridine) in the Pfizer-BioNTech and Moderna’s mRNA vaccines (but not in CVnCoV) Here we highlight the features of N1-methyl-pseudouridine and its contributions to mRNA vaccines
- Regulation and Function of RNA Pseudouridylation in Human Cells
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape that includes messenger RNA and diverse classes of non-coding RNA in human cells
- Pseudouridine: What is it and Why Should you Care?
The pseudouridine (or N1-methyl-Pseudouridine) may make synthetic mRNA-based drugs and vaccines more potent on a comparative dose-by-dose basis, but it is not necessary and this effect may be overcome by increasing the dose of non-pseudouridine modified synthetic mRNA
- Pseudouridine in RNA: what, where, how, and why - PubMed
Although pseudouridine (psi) was the first modified nucleoside to be discovered in RNA, and is the most abundant, its biosynthesis and biological roles have remained poorly understood since its identification as a "fifth nucleoside" in RNA
- Pseudouridine in a new era of RNA modifications | Cell Research - Nature
With the recent advances in the studies of dynamic RNA modifications in post-transcriptional gene expression regulation, pseudouridine comes back to the forefront
- Pseudouridines in RNAs: switching atoms means shifting paradigms
Pseudouridine (Ψ) is one of the most abundant post‐transcriptional RNA base modifications and has been detected at individual positions in tRNAs, rRNAs, mRNAs, and snRNAs, which are referred to as Ψ‐sites
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