- All Roads Lead to TREM2: Gearing Up to Target This Receptor
Since the discovery of rare, yet potent risk variants in the TREM2 gene 11 years ago, the microglial receptor has emerged as a pivot point in the pathogenesis of Alzheimer’s disease Findings presented at the International Conference on Alzheimer’s and Parkinson’s Diseases, held March 28 to
- TREM2 - ALZFORUM
Triggering receptor expressed on myeloid cells 2 (TREM2) is a receptor of the innate immune system expressed on microglia, macrophages, dendritic cells, and osteoclasts
- TREM2: A Chill Pill for Neurons? | ALZFORUM
TREM2 created quite the buzz at this year’s AD PD meeting, held April 1-5 in Vienna In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings from early phase trials of a fresh batch of agonists Juxtaposing this were presentations that unveiled a new modus operandi for
- TREM2 R47H - ALZFORUM
Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set Neurobiol Aging 2016 Jun;42:217 e7-217 e13 Epub 2016 Mar 21 PubMed Gonzalez Murcia JD, Schmutz C, Munger C, Perkes A, Gustin A, Peterson M, Ebbert MT, Norton MC, Tschanz JT, Munger RG, Corcoran CD, Kauwe JS
- TREM2 H157Y - ALZFORUM
Mutation analysis of the MS4A and TREM gene clusters in a case-control Alzheimer's disease data set Neurobiol Aging 2016 Jun;42:217 e7-217 e13 Epub 2016 Mar 21 PubMed
- TREM2 Binds Aβ, Reprograms Microglia to Curb Plaques
Importantly, the authors designed their mouse model in a way to only overexpress TREM2, excluding confounding effects by inactivating the adjacent TREM-like genes It has to be highlighted that this study further argues in favor of a beneficial rather than detrimental role of TREM2, especially in the early phases of amyloid plaque deposition
|