Application of immunohistochemistry in diagnosis and management of . . . An immunopanel including two mesothelial markers (calretinin, CK5 6, WT-1, or D2-40) and two epithelial markers (MOC-31 and claudin-4) offers good sensitivity and specificity, with adjustments as appropriate for the differential diagnosis
Claudin‐4 immunohistochemistry is highly effective in distinguishing . . . Claudin-4 is a tight-junction-associated protein that is expressed in most epithelial cells but is absent in mesothelial cells 12 Immunohistochemistry for claudin-4 has recently been shown to distinguish adenocarcinoma from malignant mesothelioma with high sensitivity and specificity, mostly in surgical specimens 13-18 Our aim was to validate
Value of claudin-4 immunostaining in the diagnosis of mesothelioma Claudin-4 (CL-4) is a tight junction-associated protein that is expressed in most epithelial cells but absent in mesothelial cells The purpose of this study is to evaluate the utility of CL-4 immunostaining for assisting in the differential diagnosis of mesothelioma
Claudin 4 identifies a wide spectrum of epithelial neoplasms and . . . The results indicate that claudin 4 is expressed by the majority of epithelial neoplasms with capacity to metastasize to pleura and peritoneum, while is consistently negative in mesothelioma Claudin 4 is a candidate to be included as a primary reagent in the panel of antibodies to assist the diagnosis of tumors involving serosal cavities
Morphology and immunohistochemical and molecular markers for diagnosis . . . Claudin 4 has recently emerged as an excellent marker of epithelial differentiation Newer IHC stains have been proposed to separate benign from malignant mesothelioma, with the most notable and widely used being BAP1 and MTAP Many of these IHC markers have been tied to prognosis
Claudin-4 shows superior specificity for mesothelioma vs non–small-cell . . . We conclude that claudin-4 has considerably greater specificity and comparable sensitivity to MOC-31 and Ber-EP4 for distinguishing NSCLC from epithelioid malignant mesothelioma The use of all three markers may be necessary for sarcomatoid neoplasms, given their limited sensitivity
Diagnostic value of claudin-4 marker in pleural and peritoneal effusion . . . Several markers have been used to make a distinction between metastatic adenocarcinoma and reactive mesothelial cells in the body cavity effusions This study aimed to evaluate the diagnostic value of claudin-4 marker in making such a distinction