- The roles of rabies virus structural proteins in immune . . .
Functions of five structural proteins of rabies virus (RABV) in viral replication and immune evasion The nucleoprotein (N), phosphorylated protein (P), matrix protein (M), glycoprotein (G), and and large subunit (L) of RNA-dependent RNA polymerase protein (RdRp) of RABV are circled in pink
- Structure of the rabies virus glycoprotein trimer bound to a . . .
The rabies virus glycoprotein (RABV-G) is the only surface-exposed protein on the virus and is the target of vaccine-elicited neutralizing antibodies RABV-G shares 57 to 78% protein sequence identity with other lyssaviruses but only ~20% identity with other rhabdoviruses
- Immunogenicity and Antigenicity of the Ectodomain of Rabies . . .
Taking all these findings into account, the rRABV G protein generated in this study exhibits promise as a potential vaccine candidate for the prevention of rabies Keywords: Rabies virus, Envelope glycoprotein, Secretory expression, Lentiviral vector, HEK 293T
- Rabies Virus Proteins and their Mechanism of Pathogenecity
Rabies is transmitted by bites of a rabid animal The rabies virus encoded five proteins, namely glycoprotein, nucleoprotein, phosphoprotein, matrixprotein and RNA dependent RNA transcriptase protein
- Rabies virus glycoprotein: Structure, function, and antivirals
The rabies virus (RABV) is a prevalent etiological agent of rabies The virus belongs to the Lyssavirus genus within the Rhabdoviridae family [2] It is visually characterized by its distinctive bullet-shaped form and possesses a single-stranded negative-sense RNA genome that encodes five critical proteins: nucleoprotein (N), phosphoprotein (P), matrix protein (M), glycoprotein (G), and RNA
- AP3B1 facilitates PDIA3 ERP57 function to regulate rabies . . .
Rabies virus causes an estimated 59,000 annual fatalities worldwide and promising therapeutic treatments are necessary to develop In this study, affinity tag-purification mass spectrometry was employed to delineate RABV glycoprotein and host protein interactions, and PDIA3 ERP57 was identified as a …
- Molecular optimization of rabies virus glycoprotein expression in
secretory pathway Secretory protein production usually requires the presence of a secretion signal sequence at the N-terminus of the foreign protein to target it to the secretory pathway; different secretion signals are avail-able to target protein secretion in P pastoris, such as PHO1 secretion signal (Chang et al , 1986) and Saccha-
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