- DNA damage and genome instability by G-quadruplex . . . - PNAS
We have investigated the interplay of G4s with R loops, another noncanonical DNA structure, and the findings reveal a mechanism of genome instability and cell killing by G4 ligands, particularly effective in cancer cells deficient of BRCA2 activity
- DNA G-quadruplex structures: more than simple roadblocks to . . .
G4 formation stabilizes R-loops In addition to nucleosome free DNA, a further structural requirement of transcription is the ability of duplex DNA to be unwound into single strands, one of which acts as the template strand for RNA polymerase, whilst the other is denoted the non-template strand
- Intertwining roles of R-loops and G-quadruplexes in DNA . . .
The observation that R-loops and their associated G4s can regulate TAD boundary strength and chromatin loop formation raises the obvious question of whether CTCF directly interacts with R-loops or G4 structures
- R-loop induced G-quadruplex in non-template promotes . . . - Nature
Together, our results reveal the intrinsic effect of PQS in both orientations and the persistent, yet dynamic formation of R-loop and G4 structures, which lead to enhanced transcription
- Simultaneous probing of transcription, G-quadruplex, and R-loop
During transcription, G-rich sequences in the non-template strand promote R-loop formation in the DNA template strand These R-loops induce G4 structures in the non-template DNA strand, further stabilizing them
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