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- TOP1 Gene - GeneCards | TOP1 Protein | TOP1 Antibody
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA
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- Topoisomerase I in Human Disease Pathogenesis and Treatments
Mammalian topoisomerase 1 (TOP1) is an essential enzyme for normal development TOP1 relaxes supercoiled DNA to remove helical constraints that can otherwise hinder DNA replication and transcription and thus block cell growth
- TOP1 Mutations and Cross-Resistance to Antibody-Drug . . . - PubMed
Purpose: Antibody-drug conjugates (ADC) harboring topoisomerase I (TOP1) inhibitor payloads have improved survival for patients with metastatic breast cancer However, knowledge of ADC resistance mechanisms and potential impact on the sequential use of ADCs is limited
- TOP1 DNA topoisomerase I [ Homo sapiens (human) ] - National Center for . . .
Title: Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states TDP1 and TOP1 as targets in anticancer treatment of NSCLC: Activity and protein level in normal and tumor tissue from 150 NSCLC patients correlated to clinical data
- Topoisomerase 1 prevents replication stress at R-loop-enriched . . . - Nature
To identify toxic R-loops in the human genome, here, we map RNA:DNA hybrids, replication stress markers and DNA double-strand breaks (DSBs) in cells depleted for Topoisomerase I (Top1), an enzyme
- Entry - *126420 - TOPOISOMERASE, DNA, I; TOP1 - OMIM
Juan et al (1988) mapped the TOP1 gene to 20q12-q13 2 by a combination of in situ hybridization and somatic cell hybridization They showed that the human TOP1 is a single-copy gene
- Targeting Topoisomerase I in the Era of Precision Medicine
We introduce new therapeutic strategies based on novel TOP1 inhibitor chemical scaffolds including the indenoisoquinolines LMP400 (indotecan), LMP776 (indimitecan) and LMP744, and on tumor-targeted delivery TOP1 inhibitors (TTTis) using liposome, PEGylation and antibody-drug conjugates
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