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Canada-0-DECALS Azienda Directories
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Azienda News:
- Dysregulated lung stroma drives emphysema exacerbation by potentiating . . .
Wang et al show that alteration of a COPD variant gene in the stroma can potentiate tissue-resident lymphocyte expansion that suppresses stem cell renewal, leading to loss of barrier surface and emphysema in the lung
- Dysregulated lung stroma drives emphysema exacerbation by potentiating . . .
Here, we sought to define these interactions in emphysema, a progressive disease characterized by infectious exacerbations and loss of alveolar epithelium Single-cell analysis of human emphysema lungs revealed the expansion of tissue-resident lymphocytes (TRLs)
- Dysregulated lung stroma drives emphysema exacerbation by potentiating . . .
Taken together, our data demonstrate that a dysregulated lung stromal niche can expand TRL numbers and topography, leading to pathologic suppression of an IFN-sensitive alveolar stem cell subset that is progressively lost in emphysema
- Dysregulated lung stroma drives emphysema exacerbation by potentiating . . .
Here, we sought to define these interactions in emphysema, a progressive disease characterized by infectious exacerbations and loss of alveolar epithelium Single-cell analysis of human
- 研究揭示肺基质失调导致肺气肿加重的机制—小柯机器人 . . .
美国加州大学Tien Peng研究组发现肺基质失调通过增强常驻淋巴细胞抑制上皮干细胞库导致肺气肿加重。 2023年2月22日，国际知名学术期刊《免疫》发表了这一成果。 他们试图在肺气肿中定义这些相互作用，肺气肿是一种以感染性加重和肺泡上皮缺失为特征的进行性疾病。 人肺气肿的单细胞分析揭示了组织驻留淋巴细胞（TRL）的扩张。 小鼠研究确定了表达Hhip的TRL的基质生态位，Hhip是一种在肺气肿中下调的疾病变异基因。 Hhip的基质特异性缺失诱导了由过度活跃的刺猬-IL-7轴介导的肺中TRL的地形扩张。 3D免疫干细胞类器官和病毒恶化的动物模型表明，扩增的TRL通过干扰素γ（IFNγ）抑制肺泡干细胞生长。 最后，他们发现了一个IFNγ敏感的人肺泡干细胞亚群，该亚群在肺气肿中优先丢失。
- Dysregulated lung stroma drives emphysema exacerbation . . .
Aberrant tissue-immune interactions are the hallmark of diverse chronic lung diseases Here, we sought to define these interactions in emphysema, a progressive disease characterized by infectious exacerbations and loss of alveolar epithelium
- Dysregulated lung stroma drives emphysema. . . : Immunity
Wang et al show that alteration of a COPD variant gene in the stroma can potentiate tissue-resident lymphocyte expansion that suppresses stem cell renewal, leading to loss of barrier surface and emphysema in the lung
- Dysregulated lung stroma drives emphysema exacerbation by potentiating . . .
Here, we sought to define these interactions in emphysema, a progressive disease characterized by infectious exacerbations and loss of alveolar epithelium Single-cell analysis of human emphysema lungs revealed the expansion of tissue-resident lymphocytes (TRLs)
- Dysregulated lung stroma drives emphysema exacerbation by potentiating . . .
Here, we sought to define these interactions in emphysema, a progressive disease characterized by infectious exacerbations and loss of alveolar epithelium Single-cell analysis of human emphysema lungs revealed the expansion of tissue-resident lymphocytes (TRLs)
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