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Azienda News:
- TransGEM: a molecule generation model based on Transformer with gene . . .
The TransGEM model can generate drug-like molecules with therapeutic potential for a specific disease solely based on disease-associated gene expression data The model consists of gene expression encoder, molecule embedding layer, Transformer decoder, and generator
- TransGEM: a molecule generation model based on Transformer with gene . . .
Gene expression profiles can be used to characterize biological phenotypes The Transformer model can be utilized to capture the associations between gene expression profiles and molecular structures due to its remarkable ability in processing contextual information
- TransGEM: a molecule generation model based on Transformer with gene . . .
The Transformer model can be utilized to capture the associations between gene expression profiles and molecular structures due to its remarkable ability in processing contextual information
- TransGEM: a molecule generation model based on Transformer with gene . . .
In this study, we propose a deep learning model, Gex2SGen (Gene Expression 2 SMILES Generation), to generate novel drug-like molecules based on desired gene expression profiles
- GitHub - hzauzqy TransGEM
Transformer-based model from gene expression to molecules TransGEM is a phenotype-based de novo drug design model, which can generate new bioactive molecules, independent from disease target information
- TransGEM：基于转换器和基因表达数据的分子生成模型。
The results demonstrate that the TransGEM model can generate molecules with desirable evaluation metrics and property distributions Case studies illustrate that TransGEM model can generate structurally novel molecules with good binding affinity to disease target proteins
- TransGEM: a molecule generation model based on Transformer with gene . . .
Results: We propose TransGEM (Transformer-based model from gene expression to molecules), which is a phenotype-based de novo drug de sign model A specialized gene expression encoder is used to embed gene expression difference values between diseased cell lines and their corresponding normal tissue cells into TransGEM model
- TransGEM: a molecule generation model based on Transformer with gene . . .
The TransGEM model is an end - to - end molecule generation model based on gene expression data It consists of a gene expression encoder, molecule embedding layer, Transformer decoder, and generator
- TransGEM: a molecule generation model based on Transformer with gene . . .
Bibliographic details on TransGEM: a molecule generation model based on Transformer with gene expression data
- TransGEM: a molecule generation model based on Transformer with gene . . .
TransGEM: a molecule generation model based on Transformer with gene expression data
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