|
Canada-0-Musicians Azienda Directories
|
Azienda News:
- Discovering anticancer drug target combinations via network-informed . . .
We test our network-informed signaling-based approach to discover anticancer drug target combinations on available clinical data, patient-derived breast and colorectal cancers
- Combining Targeted Therapies: Practical Issues to Consider at the Bench . . .
The article reviews the issues that must be considered when combining targeted therapies in early clinical drug development and proposes various novel trial designs that are logical for determining the efficacy of a drug or drug combination for personalized treatment
- A target map of clinical combination therapies in oncology . . . - Springer
This scoping review mapped these drug combinations to target pairs, which can mechanically support the future clinical combination strategy for academic or industry research
- Systematic prediction of synergistic drug combinations through network . . .
Hence, a network-based framework, TAG-CP, was proposed here to identify pre-clinical synergistic drug combinations for cancer treatment by integrating drug-target relationships into compound representation with a graph attention mechanism
- Network-based prediction of anti-cancer drug combinations
To determine the specific effects of drug combinations, such as synergistic, antagonistic, or toxic effects, we plan to model the direction of drug-target interactions by building directed graphs on existing networks, incorporating drug-target isoform networks, or introducing new node attributes
- Multi-task learning for predicting synergistic drug combinations based . . .
Experimental identification of drug combinations with synergistic effects is a time-consuming and costly process, made more difficult by the large amount of potential drug combinations Computational methods have emerged as an essential tool for predicting and prioritizing pairs of synergistic drugs
- A target map of clinical combination therapies in oncology: an analysis . . .
This scoping review mapped these drug combinations to target pairs, which can mechanically support the future clinical combination strategy for academic or industry research
- Dosing of 3 Targeted Agents in Novel Drug Combinations Used at the . . .
Determining safe and tolerable doses for novel combinations of oncology drugs is essential for a precision medicine approach, but can also require dose reductions Trametinib, palbociclib, and everolimus are among the targeted therapies most often used in novel combinations at our precision medicine clinic
- A directed weighted network-based method for drug combinations . . .
In this work, we propose a novel directed weighted network-based approach to identify drug combinations Specifically, the network is constructed on both drug-target and inter-target interactions, together with their directed regulation
- Novel Drug Combinations in Precision Medicine Are an Emerging Landscape . . .
Precision medicine is the science of individualizing treatment based on genomic alterations of a patient’s cancer Ultimately, one of the main challenges of personalized medicine is dosing, as there are limited clinical data surrounding novel combinations
|
|