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- Pseudouridine - Wikipedia
Pseudouridine is the C5-glycoside isomer of uridine that contains a C-C bond between C1 of the ribose sugar and C5 of uracil, rather than usual C1-N1 bond found in uridine Uridine is converted to pseudouridine by rotating the uridine molecule 180° across its N3-C6 axis [3]
- The Critical Contribution of Pseudouridine to mRNA COVID-19 . . .
The answer to these problems came from a well-known RNA modification, pseudouridine (Ψ), which can be used to replace uridine in the IVT mRNA It is demonstrated that Ψ can enhance RNA stability and, in the meantime, decrease anti-RNA immune response (Karikó et al , 2008)
- Pseudouridine: What is it and Why Should you Care?
In cells after polymerization, in some mRNA there are precisely controlled modifications to the “U” compounds (bases) to convert them to a different compound, called pseudouridine
- Pseudouridine Formation, the Most Common Transglycosylation . . .
Pseudouridine (Ψ) synthases are the enzymes responsible for the most abundant and phylogenetically conserved posttranscriptional modification of cellular RNAs These enzymes catalyze an isomerization reaction of specific uridine residues within an RNA chain
- Pseudouridine in RNA: what, where, how, and why - PubMed
Pseudouridine (5-ribosyluracil) is a ubiquitous yet enigmatic constituent of structural RNAs (transfer, ribosomal, small nuclear, and small nucleolar)
- Decoding pseudouridine: an emerging target for therapeutic . . .
Pseudouridine (Ψ) is the most common post-transcriptional RNA modification that is dynamically deposited throughout the transcriptome RNA pseudouridylation can influence various cellular processes, such as translation and response to environmental stress, and becomes dysregulated in disease
- pseudoUridine and Its Derivatives - BOC Sciences
Background: Pseudouridine (Ψ) is a modified nucleoside commonly incorporated into mRNA molecules to reduce the immune activation associated with mRNA-based therapeutics This modification is critical in mRNA technologies, such as vaccines, due to its ability to enhance mRNA stability and translation efficiency
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